Department of Pathology, Xiangya Hospital Central South University Changsha Hunan China. Key Laboratory of Carcinogenesis and Cancer Invasion, Ministry of Education, Department of Pathology, School of Basic Medicine Central South University Changsha Hunan China. NHC Key Laboratory of Carcinogenesis (Central South University), Cancer Research Institute and School of Basic Medicine Central South University Changsha China. Department of Oncology, Institute of Medical Sciences, National Clinical Research Center for Geriatric Disorders Xiangya Hospital Central South University Changsha Hunan China. Hunan Key Laboratory of Early Diagnosis and Precision Therapy in Lung Cancer, Department of Thoracic Surgery Second Xiangya Hospital Central South University Changsha Hunan China.